Eplerenone dose-response relationship for aldosterone blockade
نویسندگان
چکیده
منابع مشابه
Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes.
Previous studies have shown that the selective aldosterone blocker eplerenone, in doses of up to 200 mg/d, reduces albuminuria in patients with type 2 diabetes. This study was conducted to ascertain whether lower doses of eplerenone (50 or 100 mg/d) co-administered with the angiotensin-converting enzyme (ACE) inhibitor enalapril would produce a similar antialbuminuric effect while obviating the...
متن کاملSteady state aldosterone dose-response relationships.
The steady state effects of different infusion rates of aldosterone on plasma concentrations of sodium and potassium, plasma renin activity, sodium space, and mean arterial pressure were determined. Measured amounts of aldosterone were infused continuously into adrenalectomized dogs for 13 weeks. Four rates of aldosterone administration were used: 16 +/- 1 mug/day, 48 +/- 3 mug/day (approximate...
متن کاملDose-response relationship of phototherapy for hyperbilirubinemia.
BACKGROUND AND OBJECTIVE Using light-emitting diodes during conventional phototherapy, it is possible to reduce the distance from light source to infant, thus increasing light irradiance. The objective of this study was to search for a "saturation point" (ie, an irradiation level above which there is no further decrease in total serum bilirubin [TsB]). This was a prospective randomized study pe...
متن کاملA new HOPE for aldosterone blockade?
Aldosterone is increasingly recognized to play an important role in the pathophysiology of heart failure due to systolic left ventricular dysfunction (SLVD) and aldosterone blockade (AB) to be effective in reducing mortality and morbidity in patients with severe chronic heart failure and heart failure due to SLVD after myocardial infarction.1,2 AB has also been shown to reduce blood pressure an...
متن کاملEplerenone-mediated aldosterone blockade prevents renal fibrosis by reducing renal inflammation, interstitial cell proliferation and oxidative stress.
BACKGROUND/AIMS Prolonged elevation of serum aldosterone leads to renal fibrosis. Inflammation also plays a role in the pathogenesis of renal disease. We used a rat model of interstitial renal fibrosis to test the hypothesis that eplerenone-mediated aldosterone blockade prevents renal fibrosis due to its anti-inflammatory and anti-proliferative effects. METHODS Eplerenone (a selective aldoste...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2003
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(03)00519-3